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Microneedles for Drug and Vaccine Delivery and Patient Monitoring

Author Maeliosa T.C. McCrudden , Eneko Larrañeta , Thakur Raghu Raj Singh , Ryan F. Donnel
Release Date: 2018/08/01
ISBN: 9781119305149
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Book Description

Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines

Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications.

Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry.

  • The only book currently available on microneedles
  • Filled with tables, graphs, and black and white images (photographs, micrographs)
  • Authored by four experts in pharmaceutics

Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.

Table of Contents

  1. Cover
  2. Copyright
  3. List of Contributors
  4. About the Editors
  5. Preface
  6. Chapter 1: Genesis of Transdermal Drug Delivery
    1. 1.1 Skin Anatomy
    2. 1.2 Routes to Percutaneous Drug Absorption
    3. 1.3 Facilitated Transdermal Drug Delivery
    4. References
  7. Chapter 2: Microneedle Manufacturing and Testing
    1. 2.1 Introduction
    2. 2.2 Material Types, Properties and Biocompatibility
    3. 2.3 Microneedles Manufacturing and Design
    4. 2.4 Microneedle Mechanical Characterisation
    5. References
  8. Chapter 3: Microneedle‐mediated Drug Delivery
    1. 3.1 Introduction
    2. 3.2 Microneedle Drug Delivery Strategies
    3. 3.3 Conclusion
    4. References
  9. Chapter 4: Microneedle‐mediated Vaccine Delivery
    1. 4.1 Introduction
    2. 4.2 Vaccine Delivery
    3. 4.3 Intradermal Vaccination
    4. 4.4 MN Delivery of Vaccine Therapeutics
    5. 4.5 Future Perspectives
    6. References
  10. Chapter 5: Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers
    1. 5.1 Gene Therapy
    2. 5.2 DNA Vaccination
    3. 5.3 Treatment of Local Skin Diseases
    4. 5.4 Limitations of Gene Therapy
    5. 5.5 Microneedles as a Physical Delivery Strategy for Gene Therapy
    6. 5.6 Conclusions
    7. References
  11. Chapter 6: Delivery of Nanomedicines Using Microneedles
    1. 6.1 Introduction
    2. 6.2 Skin Structure and Barrier Properties Which Impact on Nanoparticle and Microparticle Penetration
    3. 6.3 Conventional Nanocarriers for Topical and Transdermal Delivery
    4. 6.4 Microneedle‐mediated Transdermal Delivery of Nanoparticles and Microparticles
    5. 6.5 Conclusions
    6. References
  12. Chapter 7: Minimally‐invasive Patient Monitoring and Diagnosis Using Microneedles
    1. 7.1 Introduction
    2. 7.2 Sampling Techniques
    3. 7.3 Microneedle Fluid Extraction Device Technical Considerations
    4. 7.4 Microneedle Innovations
    5. 7.5 Microneedle Innovations in Analyte Monitoring
    6. 7.6 Microneedle Electrode Technology
    7. 7.7 Sampling and Analytical Systems Integration
    8. 7.8 Interstitial Fluid and Blood Sampling
    9. 7.9 Developments Moving Forwards
    10. 7.10 Conclusion
    11. References
  13. Chapter 8: Delivery of Photosensitisers and Precursors Using Microneedles
    1. 8.1 Introduction
    2. 8.2 Topical Application of Photodynamic Therapy
    3. 8.3 Methods to Enhance Topical Photodynamic Therapy
    4. 8.4 Microneedles and Photothermal Therapy
    5. 8.5 Conclusion
    6. References
  14. Chapter 9: Microneedles in Improving Skin Appearance and Enhanced Delivery of Cosmeceuticals
    1. 9.1 Introduction
    2. 9.2 The Skin
    3. 9.3 Microneedling Technologies: An Evolutionary Step Towards MN Usage
    4. 9.4 Benefits of Microneedling
    5. 9.5 Commercially Available MN Devices
    6. 9.6 Patient Factors Relating to MN Devices
    7. 9.7 Delivery of Cosmeceutical Compounds
    8. 9.8 Recent Developments
    9. 9.9 Conclusion
    10. References
  15. Chapter 10: Microneedles for Ocular Drug Delivery and Targeting: Challenges and Opportunities
    1. 10.1 Introduction
    2. 10.2 Anatomy of the Eye and Barriers to Drug Delivery
    3. 10.3 Ocular Diseases and Treatments
    4. 10.4 Current Ocular Drug Delivery Systems and Administration Routes
    5. 10.5 Microneedles in Ocular Drug Delivery
    6. 10.6 MN Application Devices
    7. 10.7 MN Safety Concerns
    8. 10.8 Conclusion
    9. References
  16. Chapter 11: Clinical Translation and Industrial Development of Microneedle‐based Products
    1. 11.1 Introduction
    2. 11.2 Materials
    3. 11.3 Other Potential Applications
    4. 11.4 Patient Application
    5. 11.5 Patient/Healthcare Provider Acceptability
    6. 11.6 Patient Safety
    7. 11.7 Manufacturing and Regulatory Considerations
    8. 11.8 Commercialisation of MN Technologies
    9. 11.9 Conclusion
    10. 11.10 Future Perspectives
    11. References
  17. Index
  18. End User License Agreement
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