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Open-Space Microfluidics

Author Govind V. Kaigala , Emmanuel Delamarche
Release Date: 2018/04/01
ISBN: 9783527340385
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Book Description

Summarizing the latest trends and the current state of this research field, this up-to-date book discusses in detail techniques to perform localized alterations on surfaces with great flexibility, including microfluidic probes, multifunctional nanopipettes and various surface patterning techniques, such as dip pen nanolithography. These techniques are also put in perspective in terms of applications and how they can be transformative of numerous (bio)chemical processes involving surfaces.
The editors are from IBM Zurich, the pioneers and pacesetters in the field at the forefront of research in this new and rapidly expanding area.

Table of Contents

  1. Title Page
    1. Copyright
  2. Foreword
  3. Preface
  4. Part I: Hydrodynamic Flow Confinement (HFC)
    1. Chapter 1: Hydrodynamic Flow Confinement Using a Microfluidic Probe
      1. 1.1 Introduction
      2. 1.2 HFC Principle
      3. 1.3 MFP Heads
      4. 1.4 Vertical MFP
      5. 1.5 Advanced MFP Heads and Holders
      6. 1.6 Surface Processing Using an MFP
      7. 1.7 MFP Components
      8. 1.8 Outlook
      9. Acknowledgments
      10. References
    2. Chapter 2: Hierarchical Hydrodynamic Flow Confinement (hHFC) and Recirculation for Performing Microscale Chemistry on Surfaces
      1. 2.1 Introduction
      2. 2.2 Hierarchical HFC
      3. 2.3 Recirculation
      4. 2.4 Microscale Deposition
      5. Acknowledgments
      6. References
    3. Chapter 3: Design of Hydrodynamically Confined Microflow Devices with Numerical Modeling: Controlling Flow Envelope, Pressure, and Shear Stress
      1. 3.1 Introduction
      2. 3.2 Theory
      3. 3.3 Device and Experimental Methods for CFD Validation
      4. 3.4 Numerical Modeling of HCM devices
      5. 3.5 Envelope Size and Pressure Drop Across HCMs
      6. 3.6 Hydrodynamic Loads Generated by HCM Devices
      7. 3.7 Concluding Remarks
      8. References
    4. Chapter 4: Hele-Shaw Flow Theory in the Context of Open Microfluidics: From Dipoles to Quadrupoles
      1. 4.1 Introduction
      2. 4.2 Fundamentals of Hele-Shaw Flows
      3. 4.3 Applications to Microfluidic Dipoles and Quadrupoles
      4. 4.4 Diffusion in Hele-Shaw Flows
      5. 4.5 Conclusion
      6. References
    5. Chapter 5: Implementation and Applications of Microfluidic Quadrupoles
      1. 5.1 Introduction
      2. 5.2 Principles and Configurations of MQs
      3. 5.3 Implementation of MQs
      4. 5.4 MQ Analysis and Characterization
      5. 5.5 Application of MQs in Biology and Life Sciences
      6. 5.6 Summary and Outlook
      7. References
    6. Chapter 6: Hydrodynamic Flow Confinement-Assisted Immunohistochemistry from Micrometer to Millimeter Scale
      1. 6.1 Immunohistochemical Analysis of Tissue Sections
      2. 6.2 Probe Heads for Multiscale Surface Interactions
      3. 6.3 Immunohistochemistry with Microfluidic Probes
      4. 6.4 Micro-IHC on Human Tissue Sections
      5. 6.5 Millimeter-Scale Immunohistochemistry
      6. 6.6 Outlook
      7. Acknowledgments
      8. References
    7. Chapter 7: Local Nucleic Acid Analysis of Adherent Cells
      1. 7.1 Introduction
      2. 7.2 Methods
      3. 7.3 Results
      4. 7.4 Discussion
      5. 7.5 Concluding Remarks
      6. Acknowledgments
      7. References
    8. Chapter 8: Microfluidic Probe for Neural Organotypic Brain Tissue and Cell Perfusion
      1. 8.1 Introduction
      2. 8.2 Microperfusion of Organotypic Brain Slices Using the Microfluidic Probe
      3. 8.3 Microperfusion of Live Dissociated Neural Cell Cultures Using the Microfluidic Probe
      4. 8.4 Conclusion
      5. Acknowledgments
      6. References
    9. Chapter 9: The Multifunctional Pipette
      1. 9.1 Introduction
      2. 9.2 Open Volume Probes
      3. 9.3 Detailed View on the Multifunctional Pipette
      4. 9.4 Integrated Functions
      5. 9.5 Functional Extensions and Applications
      6. 9.6 Future Technology
      7. Acknowledgments
      8. References
    10. Chapter 10: Single-Cell Analysis with the BioPen
      1. 10.1 Introduction
      2. 10.2 The Single-Cell Challenge
      3. 10.3 Superfusion Techniques
      4. 10.4 The BioPen
      5. 10.5 Application Areas
      6. 10.6 Future Technology
      7. Acknowledgments
      8. References
    11. Chapter 11: Microfluidic Probes for Single-Cell Proteomic Analysis
      1. 11.1 Introduction
      2. 11.2 Technical Requirements of Single-Cell Proteomic Analysis
      3. 11.3 Methods for Single-Cell Proteomic Analysis
      4. 11.4 Microfluidics Enabling Next-Generation Single-Cell Proteomics
      5. 11.5 Open-Ended Microwells for Proteomic and Multiparameter Single-Cell Studies
      6. 11.6 Microfluidic Probes in In Situ Single-Cell Proteomic Measurement
      7. 11.7 Outlook for Future Work with Microfluidic Single-Cell Proteomic Assay
      8. 11.8 Conclusion
      9. References
  5. Part II: Localized Chemistry
    1. Chapter 12: Aqueous Two-Phase Systems for Micropatterning of Cells and Biomolecules
      1. 12.1 Introduction
      2. 12.2 Small Molecules Applications
      3. 12.3 Cell Patterning
      4. 12.4 Conclusions
      5. Acknowledgments
      6. References
    2. Chapter 13: Development of Pipettes as Mobile Nanofluidic Devices for Mass Spectrometric Analysis
      1. 13.1 Introduction
      2. 13.2 Segmented Flow Analysis
      3. 13.3 Utility of Nano- and Micropipettes in Mass Spectrometry
      4. 13.4 Development of Nanopipette Probes for Local Sampling
      5. 13.5 MALDI-MS Analysis of Analyte Post-Nanopipette Sampling
      6. 13.6 Development of Segmented Flow Sampling
      7. 13.7 Study of Intercellular Heterogeneity
      8. 13.8 Conclusion and Outlook
      9. Acknowledgments
      10. References
    3. Chapter 14: FluidFM: Development of the Instrument as well as Its Applications for 2D and 3D Lithography
      1. 14.1 Microchanneled AFM Cantilevers
      2. 14.2 Development of the FluidFM
      3. 14.3 Calibration of Hollow Probes: Stiffness and Flow
      4. 14.4 FluidFM as Lithography Tool in Liquid
      5. 14.5 Conclusions and Outlook
      6. Acknowledgments
      7. References
    4. Chapter 15: FluidFM Applications in Single-Cell Biology
      1. 15.1 Introduction
      2. 15.2 Nondestructive Cell Manipulations
      3. 15.3 Spatial Cell Manipulation
      4. 15.4 Controlled Fluid Delivery
      5. 15.5 Mechanical Measurements
      6. 15.6 Ionic Current Measurements
      7. 15.7 Molecular Analyses
      8. 15.8 Conclusion and Future Perspectives
      9. References
    5. Chapter 16: Soft Probes for Scanning Electrochemical Microscopy
      1. 16.1 Introduction
      2. 16.2 Principles of Scanning Electrochemical Microscopy (SECM)
      3. 16.3 Soft Probes for SECM
      4. 16.4 Applications of Soft SECM Probes
      5. 16.5 Conclusions and Future Perspectives
      6. References
    6. Chapter 17: Microfluidic Probes for Scanning Electrochemical Microscopy
      1. 17.1 Introduction
      2. 17.2 Combining Microfluidics with SECM
      3. 17.3 Electrochemical Characterization
      4. 17.4 Applications
      5. 17.5 Conclusions and Outlook
      6. References
    7. Chapter 18: Chemistrode for High Temporal- and Spatial-Resolution Chemical Analysis
      1. 18.1 Introduction
      2. 18.2 Chemistrode Design and Operation
      3. 18.3 Physical Principles Governing the Transport Processes
      4. 18.4 Multiform Chemical Analysis Independent in Space and Time from Data Acquisition
      5. 18.5 Applicability for Stimuli–Response Surfaces
      6. 18.6 Challenges and Future Directions
      7. Acknowledgments
      8. References
    8. Index
  6. End User License Agreement
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