Book Description With more than 40 contributions from expert authors, this is an extensive overview of all important research topics in the field of bioengineering, including metabolic engineering, biotransformations and biomedical applications. Alongside several chapters dealing with biotransformations and biocatalysis, a whole section is devoted to biofuels and the utilization of biomass. Current perspectives on synthetic biology and metabolic engineering approaches are presented, involving such example organisms as Escherichia coli and Corynebacterium glutamicum, while a further section covers topics in biomedical engineering including drug delivery systems and biopharmaceuticals. The book concludes with chapters on computer-aided bioprocess engineering and systems biology. This is a part of the Advanced Biotechnology book series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question. Invaluable reading for biotechnologists and bioengineers, as well as those working in the chemical and pharmaceutical industries. Show and hide more
Table of Contents
Cover Related Titles Title Page Copyright List of Contributors About the Series Editors Part I: Biocatalysis Chapter 1: Introduction to Emerging Areas in Bioengineering 1.1 Biotechnology 1.2 Bioengineering 1.3 Emerging Areas 1.4 Current Volume Acknowledgments References Chapter 2: Over-Expression of Functionally Active Inclusion Bodies of Enzymes in Recombinant Escherichia coli 2.1 Introduction 2.2 Formation and Composition of IBs 2.3 Enhancement of Protein Quality and Enzymatic Activity in IBs 2.4 Applications of Enzyme-Based IBs 2.5 An Example of IBs: N-acetyl-d-neuraminic Acid Aldolase 2.6 Concluding Remarks Acknowledgments References Chapter 3: Enzymatic Reactions in Ionic Liquids 3.1 Introduction 3.2 Enzymatic Reactions in Ionic Liquids 3.3 Factors Affecting Enzymatic Reactions in Ionic Liquids 3.4 Methods to Improve Enzyme Activity and Stability in Ionic Liquids 3.5 Conclusions and Perspectives Abbreviations of Ionic Liquids References Chapter 4: Enzyme Immobilization on Nanoparticles: Recent Applications 4.1 Introduction 4.2 Preparation of Enzyme-Immobilized Nanoparticles 4.3 Application of Enzyme Nanoparticles 4.4 Conclusion and Perspectives References Chapter 5: Whole Cell Biocatalysts Using Enzymes Displayed on Yeast Cell Surface Concise Definition of Subject 5.1 Introduction 5.2 GPI-Anchoring System 5.3 C-Terminus Free Display Systems 5.4 Applications of the Yeast Cell Surface Display System for Biocatalysts 5.5 Improvement of Catalytic Activity on the Yeast Cell Surface 5.6 Conclusions References Chapter 6: Design of Artificial Supramolecular Protein Assemblies by Enzymatic Bioconjugation for Biocatalytic Reactions Concise Definition of Subject 6.1 Introduction 6.2 Protein Assembly on a Template with Specific Interaction/Reaction Sites 6.3 Protein Assembly without a Template: Self-Assembly of Protein Units 6.4 Future Prospects Acknowledgment Conflict of Interest References Chapter 7: Production of Valuable Phenolic Compounds from Lignin by Biocatalysis: State-of-the-Art Perspective 7.1 Lignin and Its Composition 7.2 Phenol Derivatives Derived from Lignin Deconstruction 7.3 Biocatalysis to Increase the Value of Lignin-Derived Phenolic Compounds 7.4 Outlook and Future Perspectives Acknowledgments References Part II: Biofuels and Renewable Energy from Biomass Chapter 8: Biofuels, Bio-Power, and Bio-Products from Sustainable Biomass: Coupling Energy Crops and Organic Waste with Clean Energy Technologies 8.1 Introduction 8.2 Sustainable Biomass for Sustainable Development 8.3 Biorefineries and Bioenergy Conversion Pathways 8.4 Conclusions References Further Reading/Resources Chapter 9: Potential Lignocellulosic Biomass Resources in ASEAN Countries 9.1 Introduction and Characterization of Lignocellulosic Biomass in ASEAN Countries 9.2 Forest Residues in ASEAN Countries 9.3 Herbaceous Plants Residues in ASEAN Countries 9.4 Agriculture Residue in ASEAN Countries 9.5 ASEAN Government Programs and Policies on Natural Biomass References Chapter 10: Volatile Fatty Acid Platform: Concept and Application 10.1 Concept of Volatile Fatty Acid Platform 10.2 Application of VFA Platform 10.3 Tasks for Commercialization References Chapter 11: Biological Pretreatment of Lignocellulosic Biomass for Volatile Fatty Acid Production 11.1 Introduction 11.2 Pretreatments to Improve VFA Production 11.3 Future Prospect and Recent Technology Development References Chapter 12: Microbial Lipid Production from Volatile Fatty Acids by Oleaginous Yeast 12.1 Introduction 12.2 VFAs as a Carbon Source 12.3 Quality of Yeast Lipid 12.4 Conclusion Acknowledgments References Chapter 13: Gasification Technologies for Lignocellulosic Biomass 13.1 Introduction 13.2 Gasification of Lignocellulosic Biomass 13.3 Overview of Gasification Technologies of Lignocellulosic Biomass 13.4 Classification of Gasification Technologies 13.5 Types of Gasification Systems 13.6 Performance Evaluation of Biomass Gasifiers 13.7 Industrial Biomass Gasification Plants 13.8 Conclusion References Chapter 14: Separation of Butanol, Acetone, and Ethanol 14.1 Gas Stripping 14.2 Liquid–Liquid Extraction 14.3 Adsorption 14.4 Pervaporation 14.5 Distillation 14.6 Conclusion References Chapter 15: Overview of Microalgae-Based Carbon Capture and Utilization 15.1 Introduction 15.2 Capturing of Inorganic Carbon Using Photosynthesis 15.3 Microalgal Biofuel Production 15.4 Application of Microalgal By-Products 15.5 Conclusion References Chapter 16: Bioengineering of Microbial Fuel Cells: From Extracellular Electron Transfer Pathway to Electroactive Biofilm 16.1 Microbial Fuel Cells: General Concept and Extracellular Electron Transfer 16.2 Electroactive Biofilm Meets with Biocompatible Materials 16.3 Bioengineering of Electroactive Biofilm: From Bacteria to Ecosystem 16.4 Conclusions and Future Perspectives Acknowledgments References Part III: Synthetic Biology and Metabolic Engineering Chapter 17: Genome Editing Tools for Escherichia coli and Their Application in Metabolic Engineering and Synthetic Biology 17.1 Introduction 17.2 Homologous Recombination-Mediated Tools 17.3 Single-Strand DNA-Mediated Recombination 17.4 Conclusion References Chapter 18: Synthetic Biology for Corynebacterium glutamicum: An Industrial Host for White Biotechnology 18.1 Introduction 18.2 Synthetic Elements of Synthetic Biology for C. glutamicum 18.3 Conclusion and Outlook References Chapter 19: Metabolic Engineering of Solventogenic Clostridia for Butanol Production 19.1 Introduction 19.2 Biomass and Its Metabolism 19.3 Metabolic Engineering of Clostridia 19.4 Concluding Remarks and Future Perspectives References Chapter 20: Metabolic Engineering of Microorganisms for the Production of Lactate-Containing Polyesters Acknowledgments References Chapter 21: Microbial Metabolic Engineering for Production of Food Ingredients 21.1 Metabolic Engineering 21.2 Biological Production of Functional Food Materials 21.3 Future Prospects References Part IV: Products Chapter 22: Application of Lactic Acid Bacteria for Food Biotechnology Concise Definition of Subject and Its Importance 22.1 Lactic Acid Bacteria 22.2 Expression Systems in LAB 22.3 In silico Metabolic Pathway Model for LAB 22.4 The Prospect: Lactic Acid Bacteria as an Edible Therapeutic Probiotics References Chapter 23: Biopolymers Based on Raw Materials from Biomass 23.1 Introduction 23.2 Poly(butylene succinate) 23.3 Conclusion References Chapter 24: Bacterial Biofertilizers: High Density Cultivation 24.1 Introduction 24.2 Cultivation Strategies for a Few Important Bacterial Inoculants Conflict of Interest References Part V: Biosensing and Nanobiotechnology Chapter 25: Current Research in Korean Herbal Cosmetics 25.1 Introduction 25.2 Korean Herbal Medicine and Bioscience 25.3 Bioprocessing of Natural Compounds in Traditional Herbal Medicine 25.4 Skin Delivery Systems in Cosmetics 25.5 Conclusions References Chapter 26: Advanced Genetic Engineering of Microbial Cells for Biosensing Applications 26.1 Introduction 26.2 Genetic Engineering of Microbial Reporter Cells 26.3 Methods to Immobilize Cells and Maintain Cell Viability 26.4 Microbial Biosensors Based on Transducers 26.5 Conclusion and Future Prospects Acknowledgments References Chapter 27: Bioelectronic Nose 27.1 Introduction 27.2 Concept of Bioelectronic Nose 27.3 Primary Transducer for Bioelectronic Nose 27.4 Secondary Transducer for Bioelectronic Nose 27.5 Applications 27.6 Conclusion Acknowledgment References Chapter 28: Noninvasive Optical Imaging Techniques in Clinical Application 28.1 Fluorescence Diagnosis of Skin or Mucosa 28.2 Fluorescence Endoscopic Surgery 28.3 Fluorescence Image-Guided Intraoperative Open Surgery 28.4 Conclusion Acknowledgments References Chapter 29: Advanced Short Tandem Repeat Genotyping for Forensic Human Identification 29.1 DNA Sample Sources and Collection 29.2 DNA Extraction from Biological Sources 29.3 Short Tandem Repeat Markers and Commercial Kits 29.4 Amplification of STR Loci 29.5 Capillary Electrophoretic Separation of STR Amplicons 29.6 Total Integrated Forensic STR Typing System 29.7 Conclusion References Chapter 30: DNA Microarray-Based Technologies to Genotype Single Nucleotide Polymorphisms 30.1 Allele-Specific Oligonucleotide Competitive Hybridization (ASOCH) 30.2 Zip-Code Microarray 30.3 Universal Amplification-Based Technology 30.4 Bead Array Platform-Based SNP Genotyping 30.5 Conclusion References Chapter 31: Advanced Applications of Nanoscale Measuring System for Biosensors Chapter Outline 31.1 Nanoscale Gravimetric Measuring System for Chiral Recognition 31.2 Nanoscale Measuring System Using Two-Photon-Adsorbed Photopolymerization for Biosensors 31.3 Nanoscale Measuring Systems Using AFM for Biosensors 31.4 Nanoscale Measuring Systems with Nanoscale Motion Detection References Chapter 32: Biosynthesis and Applications of Silver Nanoparticles Concise Definition of Subject 32.1 Introduction 32.2 Silver Nanoparticles 32.3 Plants in Nanoparticle Synthesis 32.4 Parameters Affecting Synthesis of AgNPs 32.5 Mechanism of AgNP Synthesis 32.6 Applications of AgNPs 32.7 Conclusion References Part VI: Biomedical Engineering and Biopharmaceuticals Chapter 33: Smart Drug Delivery Devices and Implants 33.1 Introduction 33.2 External Drug Delivery Devices 33.3 Internal Drug Delivery Implants 33.4 Image-Guided Drug Delivery Systems 33.5 Summary and Perspectives Acknowledgments References Chapter 34: Controlled Delivery Systems of Protein and Peptide Therapeutics 34.1 Introduction 34.2 Drug Delivery Systems for Protein and Peptide Therapeutics 34.3 Clinical Development of Protein and Peptide Delivery Systems 34.4 Summary and Perspectives References Chapter 35: Cell Delivery Systems Using Biomaterials 35.1 Introduction to Cell-Based Therapeutics 35.2 Biomaterials as Cell Delivery Vehicles 35.3 Cell Delivery Strategies 35.4 Conclusion and Future Perspective References Chapter 36: Bioengineered Cell-Derived Vesicles as Drug Delivery Carriers 36.1 Introduction 36.2 Prokaryotic Cell-Derived Nanocarriers 36.3 Eukaryotic Cell-Derived Nanocarriers 36.4 Cell Membrane-Camouflaged Nanoparticles 36.5 Conclusions Acknowledgments References Chapter 37: Advanced Genetic Fusion Techniques for Improving the Pharmacokinetic Properties of Biologics Concise Definition of the Subject 37.1 Background 37.2 Fc-Fusion Technology 37.3 Albumin Fusion Technology 37.4 Transferrin Fusion Technology 37.5 CTP Fusion Technology 37.6 Summary References Chapter 38: Mussel-Mimetic Biomaterials for Tissue Engineering Applications 38.1 Introduction 38.2 Synthetic and Natural Polymer-Based Mussel-Mimetic Biomaterials 38.3 Tissue Adhesives 38.4 Biomolecule Immobilization and Drug Delivery 38.5 Concluding Remarks Acknowledgments References Chapter 39: Mass Production of Full-Length IgG Monoclonal Antibodies from Mammalian, Yeast, and Bacterial Hosts 39.1 Mass Production of Biosimilar Monoclonal Antibodies in Mammalian Cells 39.2 Mass Production of Monoclonal Antibodies in Yeast 39.3 Mass Production of Monoclonal Antibodies in Escherichia coli 39.4 Conclusion References Chapter 40: Recent Advances in Mass Spectrometry-Based Proteomic Methods for Discovery of Protein Biomarkers for Complex Human Diseases Concise Definition of Subject 40.1 Introduction 40.2 MS-Based Proteomic Analysis Pipeline for Discovery of Protein Biomarkers 40.3 Discovery of Protein Biomarkers Using LC–MS/MS Analysis 40.4 Analysis of Proteomic Data for the Biomarker Discovery 40.5 Verification and Validation of Biomarker Candidates References Part VII: Computer-Aided Bioprocess Design and Systems Biology Chapter 41: Overview on Bioprocess Simulation 41.1 Introduction 41.2 Modeling and Design of Bioprocess 41.3 Monitoring of Bioprocess 41.4 Control of Bioprocess 41.5 Computational Fluid Dynamics in Bioprocess Simulation References Chapter 42: Bioprocess Simulation and Scheduling 42.1 The Purpose of Bioprocess Simulation 42.2 Detailed Modeling of Single Batch Bioprocesses 42.3 Design and Operation of Multiproduct Facilities 42.4 Conclusion Abbreviations References Chapter 43: Metabolism-Combined Growth Model Construction and Its Application to Optimal Bioreactor Operation 43.1 Introduction 43.2 Growth Model Construction and a Diversity of Modification Methods 43.3 Optimal Decision-Making System 43.4 Case Study 43.5 Summary Acknowledgments References Chapter 44: Software Applications for Phenotype Analysis and Strain Design of Cellular Systems 44.1 Introduction 44.2 COBRA Framework 44.3 COBRA Software Applications 44.4 Utilizing the Potential of COBRA Software Applications Suite: A Practical Case Study 44.5 Conclusions and Future Perspectives References Chapter 45: Metabolic Network Modeling for Computer-Aided Design of Microbial Interactions 45.1 Biological Computer-Aided Design of Interactions 45.2 Community Metabolic Network Reconstruction 45.3 Prediction of Interactions Using Metabolic Networks 45.4 Conclusions Acknowledgments Conflicts of Interest References Index End User License Agreement