Book Description

Why our approaches to Alzheimer's and dementia are problematic and contradictory

Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer’s disease through early detection of pre-symptomatic biological changes in healthy individuals.

Based on a meticulous account of the history of Alzheimer’s disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.

Table of Contents

  1. Cover Page
  2. Title Page
  3. Copyright Page
  4. Dedication Page
  5. Contents
  6. Acknowledgments
  7. Orientations
  8. Chapter 1: Making and Remaking Alzheimer Disease
  9. Chapter 2: Striving to Standardize Alzheimer Disease
  10. Chapter 3: Paths to Alzheimer Prevention
  11. Chapter 4: Embodied Risk Made Visible
  12. Chapter 5: Alzheimer Genes: Biomarkers of Prediction and Prevention
  13. Chapter 6: Genome-Wide Association Studies: Back to the Future
  14. Chapter 7: Living with Embodied Omens
  15. Chapter 8: Chance Untamed and the Return of Fate
  16. Chapter 9: Transcending Entrenched Tensions
  17. Afterword: Portraits from the Mind
  18. Notes
  19. Bibliography
  20. Index