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3. OPTO-ELECTRONIC INTEGRATION OF THICK-ELECTRODE DEP MICROFLUIDIC CHIP
3.6.2 CELL MOTIONS WHEN THE FIBERS ARE MISALIGNED
When the two bers are not perfectly aligned, the force acting on the cells is asymmetric, and stable
cell capture cant be achieved. According to the deviation of the center of the two bers, the cells
can be captured or rotated. When the deviation L of the center position of the ber is larger than
the cell radius r
cell
, as shown in Figure 3.13(a), the cell is pushed onto the other ber end by one of
the laser beams. Figure 3.13(b) shows a HeLa cell contact on the ber end (laser power 200 mW).
(a) (b)
Fiber
Cell
L
r
cell
Without Filter With Filter
Figure 3.13: Cell cannoy be captured when the ber alignment deviation is greater than the cell ra-
dius: (a) schematic diagram of ber alignment deviation; and (b) one HeLa cell is captured on the
ber end face.
(a)
(b)
L
r
cell
Figure 3.14: Dual bers that are misaligned in the horizontal direction cause horizontal rotation of
the cells: (a) schematic diagram of the principle; and (b) one A549 cell was rotated counterclockwise
under the action of double bers.
When the deviation L of the dual bers is smaller than the cell radius r
cell
, the force on the
cell is not collinear, and torque is generated to cause the cell to rotate. When the misalignment
occurs in the horizontal direction, the torque is in the horizontal direction, causing the cells to ro-
tate horizontally. Figure 3.14 shows that one A549 cell rotating in the horizontal direction of the
misaligned dual bers (laser power 200 mW).
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