While CBD can be an effective treatment for many, there are some people who should proceed with caution.
Pregnant or breastfeeding women: There is a lack of conclusive data on the effects of CBD on a developing fetus or a growing breastfed baby. However, some evidence suggests that CBD may cause developmental toxicity in animals, including increased fetal mortality in rats and decreased fetal body weights in rabbits.
In addition, CBD can increase levels of anadamide, a cannabinoid that occurs naturally in the body. One study found that high levels of anadamide were associated with failure to achieve an ongoing pregnancy after in vitro fertilization.
In general, it’s best to avoid unnecessary exposure to anything that’s potentially harmful during pregnancy. Having said that, you can consult with your physician, who will take into consideration the medical benefits of CBD along with your needs, as well as any potential adverse effects on a developing fetus or breastfed baby.
Children: Clinical trials of Epidiolex established CBD as safe and effective in children two years of age and older. However, due to the differences in dosing needs for children, it is best administered under the care of a physician.
Patients with liver disease: Elevated liver enzymes levels have been reported with the CBD-based drug Epidiolex, most commonly when used in conjunction with valproate, a seizure medication. Though the liver injury was generally mild, it raises the possibility of rare, but more severe liver injury.