Part 2

Design and Analysis of Formulation Experiments

Chapter 3 – Experimental Designs for Formulations

Chapter 4 – Modeling Formulation Data

Chapter 5 – Screening Formulation Components

In Part 2 we introduce the basic experimental designs that are most frequently used in practice, such as those based on the simplex. Next, we review basic response surface models used to analyze data from these types of experiments. Some unique aspects of empirical modeling—fitting equations to data—when applied to formulation data are discussed. Screening concepts and designs for screening formulations are described. We emphasize that it is important to take a broad view of the candidate components before progressing into formulation optimization.