If your website consists of mostly dynamic content, you can still benefit from implementing CloudFront.

First, CloudFront will maintain a pool of persistent connections with your origin servers. This lessens the time it takes for files to be served to your users because the number of three-way handshakes they'll need to perform is reduced.

Second, CloudFront implements some additional optimizations around TCP connections for high performance. More data is able to be transferred over the wire initially because CloudFront uses a wider initial TCP window.

Finally, implementing a CDN such as CloudFront does give you the opportunity to review your caching strategy and how you use cache-control headers. If your home page is dynamically generated, you'll get some benefit straight away by serving it via CloudFront, but the benefits will be much greater if you let CloudFront cache it for a few minutes. Again, cost, end user, and backend performance are all things you should take into consideration.