The combination of Qt with Python provides the flexibility of Qt developers, develops GUI programs in a more robust language, and presents a rapid application development platform available on all major operating systems. We introduced to you the basics of PySide and its installation procedure on Windows, Linux, and Mac systems. We went on to create our first application, which introduced the main components of creating a GUI application and the event loop. We have concluded this chapter with an awareness on how to introduce exception handling as a best practice. Moving on, we are set to create some real-time applications in PySide.