1. Import the python-docx module:

>>> import docx

2. Create a new document:

>>> document = docx.Document()

3. Add a paragraph that highlights some words in different ways, Italics, bold, and underline:
   

>>> p = document.add_paragraph('This shows different kinds of emphasis: ')
>>> p.add_run('bold').bold = True
>>> p.add_run(', ')
<docx.text.run.Run object at ...>
>>> p.add_run('italics').italic = True
>>> p.add_run(' and ')
<docx.text.run.Run object at ...>
>>> p.add_run('underline').underline = True
>>> p.add_run('.')
<docx.text.run.Run object at ...>

4. Create some paragraphs, styling them with default styles, such as List Bullet, List Number,  or Quote:

>>> document.add_paragraph('a few', style='List Bullet')
<docx.text.paragraph.Paragraph object at ...>
>>> document.add_paragraph('bullet', style='List Bullet')
<docx.text.paragraph.Paragraph object at ...>
>>> document.add_paragraph('points', style='List Bullet')
<docx.text.paragraph.Paragraph object at ...>
>>>
>>> document.add_paragraph('Or numbered', style='List Number')
<docx.text.paragraph.Paragraph object at ...>
>>> document.add_paragraph('that will', style='List Number')
<docx.text.paragraph.Paragraph object at ...>
>>> document.add_paragraph('that keep', style='List Number')
<docx.text.paragraph.Paragraph object at ...>
>>> document.add_paragraph('count', style='List Number')
<docx.text.paragraph.Paragraph object at ...>
>>> 
>>> document.add_paragraph('And finish with a quote', style='Quote')
<docx.text.paragraph.Paragraph object at 0x10d2336d8>

5. Create a paragraph in a different font and size. We'll use Arial font and a point size of 25. The paragraph will be aligned to the right:

>>> from docx.shared import Pt
>>> from docx.enum.text import WD_ALIGN_PARAGRAPH
>>> p = document.add_paragraph('This paragraph will have a manual styling and right alignment')
>>> p.runs[0].font.name = 'Arial'
>>> p.runs[0].font.size = Pt(25)
>>> p.alignment = WD_ALIGN_PARAGRAPH.RIGHT

6. Save the document:

>>> document.save('word-report-style.docx')

7. Open the word-report-style.docx document to verify its content: