Django primarily depends on WSGI for deployment. Since WSGI, unlike CGI, does not set on environment variables based on the request, the framework itself is not vulnerable to shell injections in its default configuration.

However, if the Django application needs to run other executables, then care must be taken to run it in a restricted manner, that is, with least permissions. Any parameter originating externally must be sanitized before passing to such executables. Additionally, use call() from the subprocess module to run command-line programs with its default shell=False parameter to handle arguments securely if shell interpolation is not necessary.