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Part 2: Multivalent Systems in Chemistry
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Part 2: Multivalent Systems in Chemistry
by Bart Jan Ravoo, Rainer Haag, Leonard J. Prins, Jurriaan Huskens
Multivalency
Cover
Title Page
List of Contributors
Foreword
Reference
Preface
Part 1: General Introduction to Multivalent Interactions
1 Additivity of Energy Contributions in Multivalent Complexes
1.1 Introduction
1.2 Additivity of Single Interactions – Examples
1.3 Limitations of Additivity
1.4 Cooperativity
1.5 Allostery
1.6 Conclusions
References
2 Models and Methods in Multivalent Systems
2.1 Introduction
2.2 Numerical Data Analysis
2.3 Models for Multivalent Systems
2.4 Special Multivalent Systems
2.5 Conclusions
Acknowledgments
References
3 Design Principles for Super Selectivity using Multivalent Interactions
3.1 Introduction
3.2 Super Selectivity: An Emergent Property of Multivalency
3.3 Multivalent Polymer Adsorption
3.4 Which Systems are Super Selective?
3.5 Design Principles for Super‐Selective Targeting
3.6 Summary: It is interesting, but is it useful?
Appendix 3.A: What Is Effective Molarity?
Acknowledgements
References
4 Multivalency in Biosystems
4.1 Introduction
4.2 Cell–Cell Adhesion
4.3 Phase Transition, Multivalent Intracellular Assemblies
4.4 Multivalency in the Fluid Phase, Pathogen Opsonization
4.5 Conclusion
Acknowledgment
References
Part 2: Multivalent Systems in Chemistry
5 Multivalency in Cyclodextrin/Polymer Systems
5.1 Introduction
5.2 General Perspectives of Multivalency in Cyclodextrin/Polymer Systems
5.3 Typical Examples of Multivalency in Cyclodextrin/Polymer Systems
5.4 Summary and Outlook
Acknowledgments
References
6 Cucurbit[n]uril‐Mediated Multiple Interactions]uril‐Mediated Multiple Interactions
6.1 Introduction to Cucurbit[n]uril Chemistry
6.2 Heteroternary Complexes
6.3 Homoternary Complexes
6.4 Conclusions
References
7 Multivalency as a Design Criterion in Catalyst Development
7.1 Introduction
7.2 Formation of Enzyme‐Like Catalytic Pockets
7.3 Cooperativity Between Functional Groups
7.4 Mechanistic Effects
7.5 The Dendritic Effect in Multivalent Nanozymes
7.6 Multivalent Catalysts and Multivalent Substrates
7.7 Conclusions
Acknowledgements
References
8 Multivalent Molecular Recognition on the Surface of Bilayer Vesicles
8.1 Introduction
8.2 Molecular Recognition of Vesicles
8.3 Biomimetic Vesicles
8.4 Vesicle‐based Supramolecular Materials
8.5 Conclusion
Acknowledgment
References
Part 3: Multivalent Systems in Biology
9 Blocking Pathogens by Multivalent Inhibitors
9.1 Introduction
9.2 Design of Multivalent Ligand Architectures
9.3 Multivalent Carbohydrate Ligands
9.4 Scaffold Architecture
9.5 Nano‐ and Microgels for Pathogen Inhibition
9.6 Conclusion
Acknowledgments
References
10 Multivalent Protein Recognition Using Synthetic Receptors
10.1 Introduction
10.2 Structural Properties of Protein Surfaces
10.3 Synthetic Receptors for Protein Surface Recognition
10.4 Future Perspective and Challenges
Acknowledgment
References
11 Multivalent Calixarenes for the Targeting of Biomacromolecules
11.1 Introduction
11.2 Binding to Proteins and Enzymes
11.3 Recognition of Carbohydrate Binding Proteins (Lectins)
11.4 Binding Polyphosphates, Oligonucleotides and Nucleic Acids
11.5 Conclusions
Acknowledgements
References
12 Cucurbit[n]uril Assemblies for Biomolecular Applications
12.1 Introduction
12.2 Molecular Recognition Properties of CB[n]
12.3 Control Over the Binding Affinity with CB[n]
12.4 CB[n] Recognition of Amino Acids, Peptides, and Proteins
12.5 CB[n] for Bioanalytical and Biomedical Applications
12.6 Conclusions and Outlook
Acknowledgment
References
13 Multivalent Lectin–Glycan Interactions in the Immune System
13.1 Introduction
13.2 Targeting Innate Immunity to Shape Adaptive Immunity
13.3 C‐type Lectin Receptors
13.4 Galectins
13.5 Siglecs
13.6 Conclusions
Acknowledgment
References
14 Blocking Disease Linked Lectins with Multivalent Carbohydrates
14.1 Introduction
14.2 Haemagglutinin
14.3 LecA
14.4 LecB
14.5 Galectins
14.6 Concanavalin A
14.7 Cholera Toxin
14.8 Propeller Lectins
14.9 Conclusion
Acknowledgements
References
Index
End User License Agreement
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4 Multivalency in Biosystems
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5 Multivalency in Cyclodextrin/Polymer Systems
Part 2
Multivalent Systems in Chemistry
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