To build and deploy UWP applications in your local system directly from Visual Studio, you need to set up the developer mode in the Windows developer feature set. To check and configure it, open the Windows 10 Settings app and click on Update & security.

From the left-hand side navigation panel, click on For developers, which will open the developer features screen in the right-hand side panel. To deploy and debug UWP apps from Visual Studio, you need to enable the Developer mode radio button, as shown in the following screenshot:

This will pop up a message box asking you to confirm whether you really want to turn on the developer mode. To continue, confirm the security risks by clicking the Yes button:

This will start downloading and installing the developer mode packages, which will not take more than a few minutes. You may have to restart your PC in order to use all the features: