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End User License Agreement
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End User License Agreement
by Maeliosa T.C. McCrudden, Eneko Larrañeta, Thakur Raghu Raj Singh, Ryan F. Donnel
Microneedles for Drug and Vaccine Delivery and Patient Monitoring
Cover
Copyright
List of Contributors
About the Editors
Preface
Chapter 1: Genesis of Transdermal Drug Delivery
1.1 Skin Anatomy
1.2 Routes to Percutaneous Drug Absorption
1.3 Facilitated Transdermal Drug Delivery
References
Chapter 2: Microneedle Manufacturing and Testing
2.1 Introduction
2.2 Material Types, Properties and Biocompatibility
2.3 Microneedles Manufacturing and Design
2.4 Microneedle Mechanical Characterisation
References
Chapter 3: Microneedle‐mediated Drug Delivery
3.1 Introduction
3.2 Microneedle Drug Delivery Strategies
3.3 Conclusion
References
Chapter 4: Microneedle‐mediated Vaccine Delivery
4.1 Introduction
4.2 Vaccine Delivery
4.3 Intradermal Vaccination
4.4 MN Delivery of Vaccine Therapeutics
4.5 Future Perspectives
References
Chapter 5: Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers
5.1 Gene Therapy
5.2 DNA Vaccination
5.3 Treatment of Local Skin Diseases
5.4 Limitations of Gene Therapy
5.5 Microneedles as a Physical Delivery Strategy for Gene Therapy
5.6 Conclusions
References
Chapter 6: Delivery of Nanomedicines Using Microneedles
6.1 Introduction
6.2 Skin Structure and Barrier Properties Which Impact on Nanoparticle and Microparticle Penetration
6.3 Conventional Nanocarriers for Topical and Transdermal Delivery
6.4 Microneedle‐mediated Transdermal Delivery of Nanoparticles and Microparticles
6.5 Conclusions
References
Chapter 7: Minimally‐invasive Patient Monitoring and Diagnosis Using Microneedles
7.1 Introduction
7.2 Sampling Techniques
7.3 Microneedle Fluid Extraction Device Technical Considerations
7.4 Microneedle Innovations
7.5 Microneedle Innovations in Analyte Monitoring
7.6 Microneedle Electrode Technology
7.7 Sampling and Analytical Systems Integration
7.8 Interstitial Fluid and Blood Sampling
7.9 Developments Moving Forwards
7.10 Conclusion
References
Chapter 8: Delivery of Photosensitisers and Precursors Using Microneedles
8.1 Introduction
8.2 Topical Application of Photodynamic Therapy
8.3 Methods to Enhance Topical Photodynamic Therapy
8.4 Microneedles and Photothermal Therapy
8.5 Conclusion
References
Chapter 9: Microneedles in Improving Skin Appearance and Enhanced Delivery of Cosmeceuticals
9.1 Introduction
9.2 The Skin
9.3 Microneedling Technologies: An Evolutionary Step Towards MN Usage
9.4 Benefits of Microneedling
9.5 Commercially Available MN Devices
9.6 Patient Factors Relating to MN Devices
9.7 Delivery of Cosmeceutical Compounds
9.8 Recent Developments
9.9 Conclusion
References
Chapter 10: Microneedles for Ocular Drug Delivery and Targeting: Challenges and Opportunities
10.1 Introduction
10.2 Anatomy of the Eye and Barriers to Drug Delivery
10.3 Ocular Diseases and Treatments
10.4 Current Ocular Drug Delivery Systems and Administration Routes
10.5 Microneedles in Ocular Drug Delivery
10.6 MN Application Devices
10.7 MN Safety Concerns
10.8 Conclusion
References
Chapter 11: Clinical Translation and Industrial Development of Microneedle‐based Products
11.1 Introduction
11.2 Materials
11.3 Other Potential Applications
11.4 Patient Application
11.5 Patient/Healthcare Provider Acceptability
11.6 Patient Safety
11.7 Manufacturing and Regulatory Considerations
11.8 Commercialisation of MN Technologies
11.9 Conclusion
11.10 Future Perspectives
References
Index
End User License Agreement
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WILEY END USER LICENSE AGREEMENT
Go to
www.wiley.com/go/eula
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