- Cover image
- Title page
- Copyright
- Contributor contact details
- Woodhead Publishing Series in Electronic and Optical Materials
- Preface
- Part I: Technology for DNA and RNA analysis of pathogens
- 1. Nucleic acid sequencing for characterizing infectious and/or novel agents in complex samples
- 2. Multiplexed, lateral flow, polymerase chain reaction (PCR) techniques for biological identification
- 3. Isothermal amplification of specific sequences
- 4. Bead array technologies for genetic disease screening and microbial detection
- Part II: Lab-on-chip and portable systems for biodetection and analysis
- 5. Electrochemical detection for biological identification
- 6. Conductometric biosensors
- Abstract:
- 6.1 Introduction
- 6.2 Conductometry in enzyme catalysis
- 6.3 Conductometric enzyme biosensors based on direct analysis – I: Biosensors for biomedical applications
- 6.4 Conductometric enzyme biosensors based on direct analysis – II: Biosensors for environmental applications
- 6.5 Conductometric enzyme biosensors based on direct analysis – III: Biosensors for agribusiness applications
- 6.6 Conductometric enzyme biosensors based on inhibition analysis
- 6.7 Whole cell conductometric biosensors
- 6.8 DNA-based conductometric biosensors
- 6.9 Conductometric biosensors for detection of microorganisms
- 6.10 Conclusions
- 6.11 References
- 7. Bio-chem-FETs: field effect transistors for biological sensing
- 8. Microfluidic devices for rapid identification and characterization of pathogens
- Abstract:
- 8.1 Introduction
- 8.2 Challenges and technical as well as commercial solutions
- 8.3 Pathogens and analytes
- 8.4 Chip-based analysis of protein-based analytes in microfluidic devices
- 8.5 Chip-based analysis of nucleic acid-based analytes in microfluidic devices
- 8.6 Future trends
- 8.7 Acknowledgements
- 8.8 References
- Part III: Optical systems for biological identification
- 9. Optical biodetection using receptors and enzymes (porphyrin-incorporated)
- Abstract:
- 9.1 Introduction
- 9.2 Prior research/literature
- 9.3 Binding of cells
- 9.4 Binding of a receptor to a simulated ‘toxin’
- 9.5 Binding of the simulated 'toxin' to the receptor
- 9.6 Binding of a specific antigen diagnostic of cancer to a receptor
- 9.7 Binding of cholera toxin
- 9.8 Binding of influenza
- 9.9 Conclusion
- 9.10 References
- 10. Overview of terahertz spectral characterization for biological identification
- Abstract:
- 10.1 Introduction
- 10.2 Fundamentals of terahertz vibrational spectroscopy for biological identification of large biological molecules and species
- 10.3 Overview
- 10.4 Recent and future trends
- 10.5 Approach for computational modeling of vibrational frequencies and absorption spectra of biomolecules
- 10.6 The problem with a poor convergence of simulation
- 10.7 Other problems: dissipation time scales
- 10.8 Statistical model for Escherichia coli DNA sequence
- 10.9 Component-based model for Escherichia coli cells
- 10.10 Experimental sub-terahertz spectroscopy of biological molecules and species
- 10.11 Conclusions and future trends
- 10.12 Acknowledgments
- 10.13 References
- 11. Raman spectroscopy for biological identification
- 12. Lidar (Light Detection And Ranging) for biodetection
- 9. Optical biodetection using receptors and enzymes (porphyrin-incorporated)
- Part IV: Sample preparation and mass spectrometry-based biological analysis
- 13. Electrophoretic approaches to sample collection and preparation for nucleic acids analysis
- Abstract:
- 13.1 Introduction
- 13.2 Separation parameters for nucleic acids for use in sample preparation
- 13.3 Electrophoresis using uniform electric fields for sample preparation and analysis
- 13.4 Electrophoresis using non-uniform electric field gradients for sample preparation and analysis
- 13.5 Comparison of electrophoretic techniques for sample preparation and contaminant rejection
- 13.6 Future trends
- 13.7 Sources of further information and advice
- 13.8 Acknowledgments
- 13.9 References
- 14. Mass spectrometry-based proteomics techniques for biological identification
- Abstract:
- 14.1 Introduction
- 14.2 Bacterial proteome handling, processing and separation methods
- 14.3 Sample ionization and introduction for mass spectrometry (MS) analysis
- 14.4 Mass spectral proteomic methods
- 14.5 Computational and bioinformatics approaches for data mining and discrimination of microbes
- 14.6 Peptide mass fingerprinting (PMF) and matrix-assisted laser desorption/ionization-tandem mass spectrometry (MALDI-MS/MS) of peptides
- 14.7 Analysis of MALDI-MS spectra
- 14.8 Analyses of double-blind bacterial mixtures
- 14.9 Conclusions
- 14.10 References
- 13. Electrophoretic approaches to sample collection and preparation for nucleic acids analysis
Biological Identification
DNA Amplification and Sequencing, Optical Sensing, Lab-on-chip and Portable Systems
Edited by
R. Paul Schaudies
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