Index

A

adaptive solution, 3, 39
allograft rejection, 76
ALLPATH, 14, 26
ALLPATH-LG, 14, 26
alternative splicing, 37
Ancestry, 43
Andromeda, 91
annotation, 28
ANOVA, 63
ArrayExpress, 55

B

background correction, 53
background subtraction, 53
base calling, 24
biomarker and drug co-development, 139
biosignature, 133
BLAST, 27
Bowtie, 14

C

cancer, 42, 43
cancer cell, 78
causal inference, 72
Chromas Lite, 14
chromothripsis, 43
CIRCOS, 13
clinical trials, 138
Cluster, 57
CNV, 18
codon, 84
co-immunoprecipitation, 87
collective behavior, 116
combinatorial explosion, 4
Connectivity Map, 72
contig, 25
copy number variation, 18

D

DAVID, 58, 71
dbSNP, 37
de novo peptide sequencing, 93
diplotype, 21
EBI-ASTD, 37

E

electrospray ionization (ESI), 88
enrichment analysis, 70
EnrichNet, 57
enzyme linked immunosorbent assay (ELISA), 87
e-PCR, 12
epigenomics, 85, 102

F

F1 score, 137
Flicker, 92
Follicular lymphoma, 77
Function Express at Washington University, 58
functional annotations, 69

G

gene expression microarray, 51
Gene Set Enrichment Analysis (GSEA), 72
Genecards, 13
genetic algorithm, 40
GeneXPress, 58
genome annotation, 28
genome browser, 11
genome wide association study, 30
GenomeBrowse, 13
genomic sequencing, 23
genomic structure, 10
genomic variants, 16
genotyping arrays, 17
GEO, 55
GEO2R, 55
GOEAST, 58, 71
Goldsurfer2, 37
graph theory, 96, 116
GSEA, 57
GWAS, 30

H

hallmarks of cancer, 112
haplotype, 21
HapMap, 13, 17
Hardy-Weinberg equilibrium, 33
H-DBAS, 37
heat map, 60, 61
hepatitis C, 140
heritability, 39
hierarchical clustering, 68
Human Protein Atlas, 90
human viral protein interaction, 102
hypergeometric distribution, 70

I

ill-posed problem, 1
Immuno blotting, 86
immunohistochemistry (IHC), 86
InterPro, 37, 91
inverse problem, 1

K

Kaplan-Meier curves, 135
Kolmogorov-Smirnov test, 72

L

Lillifore test, 64
LIMMA, 56
linkage disequilibrium, 19
liquid chromatography (LC), 89
LocusZoom, 15

M

M vs. A plot, 67
Manhattan plot, 37
Mann–Whitney U, 63
Mascot, 92
mass spectrom feature extraction, 92
mass spectrom matching, 93
Mass spectrometry, 87
matrix assisted laser desorption ionization (MALDI), 88
Matthew correlation coefficient, 137
MaxQuant, 91
metagenomcis, 119
micro RNA, 50
microarray data normalization, 54
microbiome, 119
Mitocheck cell-cycle genes, 111
molecular signature, 76
MRMer, 92
MS/MS ion matching, 93
multiplex reaction monitoring (MRM), 97

N

NCBI GeneBank, 11
negative predictive value (NPV), 136
non-coding RNA, 50
non-parametric test, 63
NovoSNP, 14, 24

O

Octave, 15
odds ratio, 35
omics, 4
OMIM, 13
Oncotype, 143
ontogeny, 120

P

paired test, 62
PANTHER, 57, 71, 91
Past, 56
PCA plot, 66
PDB, 91
peptide mass fingerprinting (PMF), 93
Pfam, 37, 90
phase locking, 124
phylogeny, 120
PolyPhred, 24
PolyScan, 24
positive predictive value (PPV), 136
Primer-BLAST, 12
principal component analysis (PCA), 65
prognosis, 77
PROSITE, 90
protein domains, 98
Protein identification, 89
Protein interaction networks, 89, 100
protein motif, 98
protein structure prediction, 99

Q

quality filters, 32
quantitative proteomics, 97
quantitative trait locus (QTL), 75

R

RefSNP, 37
regression, 133
relative risk, 36
renal transplantation, 76
RNA deep sequencing, 52
RNA secondary structure, 75
Robust Multiarray Analysis (RMA), 54

S

scaffold, 25
SCOP, 91
SeattleSNPs, 13
sensitivity, 136
sequence alignment, 26
sequence read assembly, 25
signal noise ratio (SNR), 62
Significance Analysis of Microarray (SAM), 56
similarity clustering, 67
SNAP, 15
SNP, 17
SNP array base calling, 28
SNP combinations, 39
SNP detector, 24
SNP tagging, 19
somatic copy number alterations, 42
somatic mutations, 18, 42
specificity, 136
stem cell, 78
summarization, 54
survival analysis, 134
SWISS-Model, 91

T

tag SNP, 19
Tandem mass spectrometry (MS/MS), 88
THESIAS, 14
transfer RNAs, 84
TreeView, 57
t-test, 62
two- channel array, 52

U

UCSC Genome Bioinformatics, 12
UGene, 14
Unweighted Pair Group Method with Arithmetic (UPGMA), 68

V

variome, 16
Velvat, 14
Vienna RNA package, 75
visualization, 11, 61
volcano plot, 61, 64

W

Warfarin, 142
Western blotting, 86
WGAviewer, 14, 37

Y

Youden index, 137
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