Table of Contents

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Title page

Copyright

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Woodhead Publishing Series in Biomaterials

Preface

Chapter 1: Introduction to biomaterials and implantable device design

Abstract:

1.1 Introduction

1.2 Biomaterials and their applications

1.3 Biomaterial development and realisation

1.4 Implantable systems design

1.5 Device-associated infections

1.6 Current trends in biomaterials design and fabrication

Chapter 2: Natural polymer biomaterials: advanced applications

Abstract:

2.1 Introduction

2.2 Chitin and chitosan

2.3 Alginate

2.4 Collagen

2.5 Gelatin

2.6 Hyaluronic acid

2.7 Fibrinogen

2.8 Silk fibroin

2.9 Viral particles and bacteriophage capsids for drug delivery

2.10 Immunocytes as ‘Trojan horses’ for molecule delivery

2.11 Future trends

Chapter 3: Advanced synthetic polymer biomaterials derived from organic sources

Abstract:

3.1 Introduction

3.2 Poly(ester)s and poly(ester) block copolymers

3.3 Poly(2-oxazoline)s

3.4 Poly(alkyl carbonate)s

3.5 Poly(ether)s

3.6 Polypeptides

3.7 Poly(anhydride)s

3.8 Poly(urethane)s

3.9 Conclusion

Chapter 4: Advanced synthetic and hybrid polymer biomaterials derived from inorganic and mixed organic–inorganic sources

Abstract:

4.1 Introduction

4.2 Synthetic inorganic polymers

4.3 Silicon-based inorganic polymers

4.4 Poly(phosphazene)s

4.5 Organic–inorganic hybrid polymers

4.6 Geopolymers

4.7 Conclusion

Chapter 5: Metallic biomaterials: types and advanced applications

Abstract:

5.1 Introduction

5.2 Stainless steel

5.3 Co-Cr alloys

5.4 Ti and Ti-based alloys

5.5 Noble metal alloys

5.6 Shape memory alloys

5.7 Biodegradable metals

5.8 Conclusion

Chapter 6: Cytotoxicity and biocompatibility of metallic biomaterials

Abstract:

6.1 Introduction

6.2 Cytotoxicity and biocompatibility of metals and alloys

6.3 Effect of load and wear on implant degradation

6.4 Macrophage-mediated inflammatory events

6.5 Role of bacterial endotoxins in triggering a particle-induced inflammatory response

6.6 Osteoclast-mediated bone resorption

6.7 Osteolysis as a function of implant-associated mechano-transduction

6.8 Surface modification as a means of enhancing biocompatibility and corrosion resistance

6.9 Conclusion

Chapter 7: Bioinert ceramic biomaterials: advanced applications

Abstract:

7.1 Introduction

7.2 Hardness, high compressive strength and wear resistance of bioinert refractory polycrystalline compounds

7.3 Techniques for the fabrication of bioinert ceramic implants

7.4 Conclusion

Chapter 8: Advanced bioactive and biodegradable ceramic biomaterials

Abstract:

8.1 Introduction

8.2 The development of bioactive ceramics for tissue engineering

8.3 Calcium phosphates

8.4 Bioactive glasses

8.5 Conclusion

Index

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