Javier Brum
Laboratorio deAcustica Ultrasonora, Instituto de Fisica, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay
Wave propagation in bounded media has been widely used in several fields (e.g. non‐destructive evaluation, seismology, underwater acoustics) to determine different material properties. Recently, ultrasound elastography, motivated by several medical applications, has used guided waves to determine, non‐invasively, the mechanical properties of plate‐like tissue, such as cornea, skin, myocardium, bladder, arteries, and tendons [1–10]. In these applications, the shear wavelength (λ ∼ 1–10 cm) is comparable to the tissue's thickness (e.g. ∼0.1 cm for arteries and skin, ∼1 cm for myocardium). As a consequence, the shear wave is guided within the tissue due to the successive reflections on the tissue boundaries. In this scenario, the relation between wave speed and elasticity is more complex than in the case of an infinite tissue, where the shear waves propagate in the bulk of the sample (i.e. away from the boundaries). To retrieve the bulk shear wave speed and therefore the shear elasticity of the plate‐like tissue, the typical sequence is the following:
In this context, the main goal of this chapter is to review the main features of transverse wave propagation in plate structures with application to ultrasound elastography. To this end, the theory of guided wave propagation developed for an elastic solid will be presented and revised for soft tissues in the experimental configurations encountered in ultrasound elastography. Several types of wave guides and boundary conditions adapted to different applications will be studied.
The exact solution to the problem of wave propagation in an elastic isotropic plate has been obtained through different approaches. The two most popular approaches are the displacement potentials method and the partial wave technique (see [11] for further reading). In this chapter the partial wave technique will be used since it is more suitable to study wave propagation in anisotropic plates. Furthermore, the partial wave technique leads to more direct wave solutions and provides a deeper insight into the physical nature of the waves.
The partial wave technique [12] is based on the fact that the field equations for the displacements and stresses in a flat plate can be written as the superposition of the fields corresponding to four bulk waves within the plate. In Figure 7.1 the case for a single plate embedded in an elastic medium is presented. Inside the plate there are four waves, two shear waves ( ) and two longitudinal waves ( ), propagating with positive ( , ) and negative ( , ) components. Due to refraction and mode conversion, these four waves create two kinds of waves in the surrounding medium: one shear wave and one compressional wave.
The first step of the method consists in deriving the field equations for bulk waves, which are solutions to the wave equation in an infinite medium. As a result the stresses and displacements within the plate can be expressed in terms of the amplitudes of all the bulk waves that can exist within that plate. Then by introducing the proper boundary conditions at each interface the rules for coupling between plate and surrounding medium are defined. Finally, the different boundary conditions can be combined into one global matrix which describes the entire system by relating the bulk wave amplitudes to the physical constraints.
In what follows it will be assumed that the wavelengths involved are smaller than the width of the plate and therefore a plane strain analysis is valid. The plane strain hypothesis restricts the model to waves whose particle motion is entirely in the ( ) plane, thus excluding for example shear horizontal (SH) modes. SH modes are usually not observed in ultrasound elastography since the ultrasound probe is placed parallel to the plate; however, they may be observed with other imaging modalities, such as MRI. (Please refer to references 11, 14, and 15 for further reading on SH modes and its inclusion into the general theory.)
Under a plane strain hypothesis, where there is no variation of any quantity in the direction, the coordinate system may be reduced to the plane defined by the wave propagation direction and the normal to the plate (see Figure 7.1). A convenient way of presenting the solutions for bulk waves inside the plate is by introducing Helmholtz potentials. The longitudinal waves (L) are described by a scalar potential while the shear waves (S) are described a vector potential whose direction is normal to the wave propagation direction and the particle motion direction.
Here and are the longitudinal and shear wave amplitudes, is the wavenumber vector, and is the angular frequency. From the potentials, the displacements of the longitudinal and shear waves can be calculated as
As stated above, the development of a model for wave motion in plates is achieved by the superposition of longitudinal and shear bulk waves and the imposition of boundary conditions at the different interfaces. For modeling the guided wave propagating along the plate it is sufficient to assume the presence of four bulk waves inside the plate: two shear waves ( ) and two longitudinal waves ( ). Each of these bulk waves is termed a partial wave.
Let be denoted by , which corresponds to the wavenumber of the guided wave. Then, the component of the wave vector of each partial wave can be expressed in terms of and the bulk wave velocities of the plate as
where the subscript stands for the longitudinal or shear partial wave, denotes the bulk phase velocity of each type of wave in the plate and the + and − signs correspond to a wave moving with positive (“downward”) and negative (“upward”) component. The displacements and stresses at any location inside the plate may be found from the amplitudes of the bulk waves using the field equations. In particular, the expressions for the two displacement components and , the normal stress , and the shear stress will be derived since in a plate system these quantities must be continuous over the different interfaces. From Hooke's law and the strain definition, the stresses can be calculated as
Thus for the longitudinal partial bulk waves it can be found
For the partial shear bulk waves
where , , and corresponds to the medium's density. The displacements and stresses at any location in the plate may be found by summing the contributions due to the four partial wave components.
The matrix in Eq. (7.10) describes the relation between the wave amplitudes and the displacements and stresses at any position inside the plate. Its coefficients depend on the through‐thickness position inside the plate, i.e. ; the material properties of the layer, i.e. ; and the frequency and wavenumber of the guided wave.
By using Eq. (7.10) it is possible to combine all the different boundary conditions at each interface into a single global matrix which represents the entire system [12]. The columns of the global matrix correspond to the amplitudes of the partial wave at each interface, while the rows correspond to each boundary condition. Thus, by multiplying the global matrix by a vector containing the partial wave amplitudes, all boundary conditions will be satisfied simultaneously. The resulting equation will always be zero providing the characteristic equation of the system
To obtain non‐trivial solutions for the vector of partial wave amplitudes , the determinant of the global matrix in Eq. (7.11) must be zero. This constraint will allow only particular wave numbers for a given frequency. By changing the frequency it is possible to find the relation , where is the phase velocity of the guided wave, i.e. the phase velocity dispersion curve. The phase velocity dispersion curve is the quantity that is usually measured in ultrasound elastography. Consequently, to retrieve the bulk shear wave speed and therefore the shear elasticity of the plate, it is necessary to fit the experimental dispersion curve to a given plate model. In what follows several plate models will be presented along with their different applications and consequences in ultrasound elastography.
Let us now apply Eq. (7.10) to study transverse wave propagation in an elastic plate in vacuum (i.e. Lamb waves). Although this situation is difficult to meet in practice it will be helpful to establish some basic concepts of guided wave propagation. These concepts will be used later in more complex situations. Let be the thickness of the plate. For a plate in a vacuum, the normal stresses should vanish at each interface (i.e. traction‐free condition): at . Under this condition Eq. (7.10) results in
By combining rows and columns, the determinant of Eq. (7.12), which determines the phase velocity dispersion curve, gives
As described by Eq. (7.13), the determinant of the global matrix is calculated as a product of two determinants. Each determinant corresponds to one particular mode of propagation: the one on the left corresponds to the symmetric modes while the one on the right to corresponds to the anti‐symmetric modes. For the symmetric modes the longitudinal component of the displacement field ( ) is an even function of while the transverse component ( ) is an odd function of . On the contrary, for the anti‐symmetric modes, while is an even function, is an odd function of . Consequently, for each mode, the plate movement is either symmetric or anti‐symmetric with respect to the median plane of the plate. In Figure 7.2 the phase velocity dispersion curve along with a schematic of the plate movement is presented for the different modes. The anti‐symmetric and symmetric modes are denoted with letters and respectively, where the subscript . indicates the order of the mode.
By expanding each determinant in Eq. (7.13) the following characteristic equation is found for the symmetric (Eq. 7.14) and anti‐symmetric modes (Eq. 7.15) respectively
It may be observed in Figure 7.2 that several modes ( ) present a cut‐off frequency. Near the cut‐off frequency therefore , and . Consequently, from Eq. (7.10), the displacement field and stresses near the cut‐off frequency may be expressed as
where the first term of each equation corresponds to the anti‐symmetric modes and the second to the symmetric modes. For the symmetric modes, the even solutions ( .) correspond to an even displacement field, therefore . Consequently, the corresponding boundary condition gives
This corresponds to a pure longitudinal symmetric mode. On the contrary, the odd solutions with ., correspond to , giving
which corresponds to a pure transverse mode. For the anti‐symmetric modes the same reasoning yields the following cut‐off frequencies
for the even ( .) and odd ( .) anti‐symmetric modes respectively.
At this point, it is important to notice the consequences of Eqs. (7.20)–(7.22) for Lamb wave propagation in soft tissues. In ultrasound elastography ∼ 1500 m/s, ∼ 1–20 m/s, ∼ 1–20 mm, and the frequency is usually below 2 kHz. Therefore, the even anti‐symmetric and the odd symmetric modes will not be generated in an ultrasound elastography experiment since the lowest for these modes is ∼ 7.5 kHz (Eq. 7.21). On the contrary, the presence of the even symmetric modes and the odd anti‐symmetric modes will depend on frequency and on the ratio (Eqs. 7.20 and 7.23). For tissues such as skin, arteries, bladder, or cornea where ∼ 1–3 mm, the for these modes will lie in the kHz range and they will not be generated. Consequently, for these kind of tissues the only modes that may be expected are the zero‐order symmetric ( ) and anti‐symmetric ( ) modes, which have no cut‐off frequency. For other types of tissue, e.g. the myocardium, where ∼ 1 cm and ∼ 5 m/s, the cut‐off frequencies for is ∼250 Hz, for is ∼500 Hz, etc. Therefore, these modes may eventually coexist with the and modes, depending on the type of source, frequency, plate thickness, and shear elasticity involved in the experiments. It is important to point out, that although these modes may theoretically be present, to our knowledge they have not been detected yet in a plate of soft tissue. This may be explained by the fact that, as seen above, the odd anti‐symmetric and symmetric modes are mainly longitudinal near the cut‐off frequencies, which, combined with a strong attenuation for frequencies above ∼400 Hz (i.e. tissue is by nature viscoelastic), makes it very difficult to detect them in the experiments. Consequently, the most common situation in an elastography experiment is the presence of the and modes. Let us briefly present the main features of these modes.
In the low‐frequency approximation, i.e. as and approach to zero, Eq. (7.14) and Eq. (7.15) may be reduced to
From Eq. (7.24), the phase velocity for tends to a finite limit given by , which for a soft tissue ( ) may be approximated as . Additionally, it may demonstrated that when , the mode is essentially longitudinal, i.e. [15]. Since soft tissue is incompressible, a longitudinal displacement will generate a small but non‐negligible transverse displacement (see Figure 7.2b), therefore, this mode may be eventually detected by using ultrasound elastography. Additionally, the velocity of the mode is close to and may be followed by an ultrafast scanner. For , by using Eq. (7.25), it may be demonstrated that its phase velocity may be approximated as
Therefore, by fitting this expression to the experimental dispersion curve the value of may be retrieved without cumbersome determinant calculations. In the high‐frequency region, i.e. , the velocities of the and approach to Rayleigh wave velocity which is ∼ . Therefore the phase velocity for the and modes will always lie between zero and .
Finally, it is important to point out that the generation of each mode will not only depend on the frequency, but also on the type of source used in the experiments [11]. A type of source which is common in ultrasound elastography is the radiation force of ultrasound. This type of source acts all along the thickness of the plate in a direction perpendicular to the plate, generating mainly the mode, which is a flexural mode (Figure 7.2b).
Let us study a more realistic situation than a plate in vacuum. The model of a viscoelastic plate surrounded by non‐viscous fluid has widely been used to determine in vivo and ex vivo the shear elasticity and viscosity of several types of tissues, e.g. arteries [6, 7], cornea [1, 16, 17], bladder [5], and myocardium [3, 18]. In these works the Lamb waves were generated by using the acoustic radiation force of focused ultrasound, generating only mode. Therefore, in what follows, special attention will be devoted to this specific mode of propagation.
Let us derive the dispersion equation for an elastic plate in liquid by using the partial wave technique introduced in Section 7.2.2. For a plate embedded in a non‐viscous fluid of density and longitudinal wave velocity , six partial waves should be taken into account. The four waves inside the plate create two longitudinal waves ( , ) in the surrounding fluid. By applying the continuity at each interface of , , and the global matrix governing the system can be written as
where * denotes complex conjugate, , and , , correspond to the surrounding liquid. By combining rows and columns the determinant of may be calculated as a product of two sub‐determinants which give the following characteristic equations
Equations (7.28) and (7.29) correspond to the symmetric and anti‐symmetric modes respectively. It is important to notice that these equations differ from the equations for a plate in vacuum (Eqs. 7.14 and 7.15) by one term which takes into account the contribution of the fluid. In Figure 7.3 the phase velocity dispersion curves for the different modes for a plate in water (circles) are compared to the dispersion curves for a plate in vacuum (black dots).
Contrary to what happens for a plate in a vacuum, where the acoustic energy is trapped inside the plate, for a plate surrounded by fluid the energy may leak into the surrounding medium. Leakage may be described by an amplitude exponential reduction with distance along the plate, which can be expressed by a complex wavenumber . The real part of the wavenumber is related to the phase velocity and describes the harmonic wave propagation while the imaginary part describes the wave attenuation in space.
Leakage will depend on the ratio between the phase velocity of each mode and the bulk velocities of the plate. Snell's law requires that all the partial waves share the same frequency and spatial properties in the direction at each interface. This constrains the angles of incidence, transmission, and reflection of the partial waves inside the plate by
where are the angles at which longitudinal and shear partial waves propagate with respect to the direction. Therefore, a leakage angle, , may be determined as . Therefore, if , the leakage angle would be imaginary, which means that instead of creating a wave that propagates away from the plate, the displacements will decay exponentially and energy will be trapped in the fluid region close to the plate. [The same conclusion is obtained from Eq. (7.5): if is smaller than then is imaginary and the wave is evanescent in the direction.] Consequently, a mode will not leak if its phase velocity is less than the bulk velocity of any waves that can exist in the surrounding medium. In elastography, since and , the phase velocities of the different measurable modes will be lower than (see Figure 7.3) and no leakage should be considered. Therefore, when solving Eqs. (7.28) and (7.29) real values of should be searched.
Another source of wave attenuation is viscosity, which is inherent to any type of tissue. In many applications viscosity had to be taken into account to properly model the guided wave propagation. To introduce viscosity, the elastic constant will no longer be considered as a real number but as a complex number instead. For example, if the frequency dependence is assumed to obey a Voigt model, as it was assumed in previous works [3, 9, 18], then may be written as
where is the elastic component and is the viscous component or viscosity. [Other rheological models, such as Maxwell or Zener, will introduce different relations than the one presented in Eq. (7.31); please refer to Fung [19] for further details.] It is important to note that the partial wave technique still remains valid in the presence of viscosity [12]; however, to solve Eqs. (7.28) and (7.29) complex wavenumbers should be searched: the real part is related to the phase velocity and the imaginary part is related to wave attenuation. In Figure 7.4 the phase velocity and attenuation dispersion curves for different values of viscosity are presented. In this figure , with Re[ ] being the real part.
From Figure 7.4, it is important to point out, that while the phase velocity dispersion curve differs from the pure elastic case (the solid line) for values of f·h/c T > 0.15, for f·h/c T < 0.1 they practically remain unchanged when viscosity is added. On the other hand, the attenuation dispersion curve is clearly sensitive to viscosity. This effect has already been observed by Nguyen et al. [2] for Lamb waves in viscoelastic isotropic plates and by Brum et al. [9] for guided wave propagation in the Achilles tendon. Consequently, for low values of f·h/c T, the elasticity constant associated with the guided wave can be retrieved directly from the phase velocity dispersion curve independently of the viscosity effects, i.e. elasticity and viscosity are uncoupled.
An empirical formula (Eq. 7.32) was first proposed by Couade et al. [6] to retrieve the shear modulus of the arterial wall from the dispersion curve by assuming the artery to behave as an elastic plate in water.
This formula introduces a correction factor of when compared to the low‐frequency approximation of the mode for a plate in vacuum (Eq. 7.26).
The validity of this empirical formula was discussed in the work of Nguyen et al. [2] in the case of thin elastic plates submerged in water. In this work, Eq. (7.32) was tested for plate thicknesses and shear wave speeds ranging between 0.5 and 1.5 mm and 5 and 10 m/s respectively, showing that the relative deviation of the empirical formula from simulated dispersion curves is as much as 15% for the thickest and softest plates. However, its deviation was less than 5% for plates of 1 mm thickness whose shear wave speeds were greater than 10 m/s. Therefore, this empirical formula is suitable for some particular applications, e.g. elasticity estimation of cornea, skin, or the arterial wall.
The model of an isotropic plate surrounded by two semi‐infinite elastic solids of bulk waves speed and has been used in vitro by Brum et al. [13] to measure the elasticity of thin plates embedded in an elastic solid and numerically by Couade et al. [6] to establish the bias of the Leaky lamb model used in their work with respect to other plate models with more realistic boundaries conditions.
For a plate embedded in an elastic medium eight partial waves should be taken into account (see Figure 7.1). The four waves inside the plate create two kinds of waves in the surrounding medium: one shear and one longitudinal wave propagating with positive ( , ) and negative ( , ) component. As a consequence at each interface six partial waves should be taken into account. By applying the continuity at each of the interfaces of , , , and the global matrix governing the system can be written as
For the equation of , , and with a superscript with , the bulk wave speeds and density of each semi‐infinite solid should be used. For the particular case of , Brum et al. [13] demonstrated that the determinant of may be reduced to a product of two determinants
The determinant on the left corresponds to the anti‐symmetric modes and the one on the right to the symmetric modes. Since the plate is embedded in an elastic medium, leakage will occur whenever the phase velocity of the guided wave exceeds one of the bulk wave velocities of the surrounding medium. Since in elastography , leakage will mainly depend whether is greater or less than the shear wave speed of the surrounding medium. Therefore, complex wavenumbers should be searched when solving Eq. (7.34).
Transverse isotropic tissue like tendons and muscles are commonly present in ultrasound elastography. Recently, guided wave propagation along a transverse isotropic plate has been used to model shear wave propagation in vivo in the human Achilles tendon [9, 10]. Another example lies in the cornea [17]. Let us briefly describe the main features of guided wave propagation along transverse isotropic plates.
For an isotropic solid only two constants (i.e. Lamé constants) are needed to characterize it. On the contrary, for a transverse isotropic solid the Christoffel's tensor describing the system is composed of five independent elastic constants: , , , , and . In an infinite transverse isotropic medium the elastic constants , , and can be determined from the measurement of longitudinal ultrasound phase velocities along the perpendicular and parallel directions, respectively. Moreover, the elastic constants and can be deduced from the phase velocity measurement of shear waves propagating either parallel or perpendicular to the fibre direction with a polarization perpendicular to the fibers [20]. However, in a transverse isotropic plate the relation between phase velocity and elasticity is more complex. Let us use the partial wave technique to derive the secular equation for a transverse isotropic plate. Two situations will be considered: parallel and perpendicular to the fiber orientation.
Let us first consider the case where the wave propagation direction is parallel to the fibers. A plane wave traveling in an arbitrary direction x may be written as
where is the displacement vector and is its amplitude. Under a plane strain condition, the nature of the bulk plane waves which can exist within a transverse isotropic plate are determined by Christoffel's equation
Thus, by combining Eq. (7.35) and Eq. (7.36), the following equations relating the plane wave amplitudes and are deduced
From Eq. (7.37) it is possible to express the ratio R between the wave amplitudes and as
By eliminating and from Eq. (7.38) by using Eq. (7.39), the following quadratic equation for in terms of and the elastic constants is deduced
where and are given by
Let us define and as the two values of obtained from Eq. (7.40) with + and – signs respectively. Also, and will denote the value of when and are respectively substituted in Eq. (7.39).
The equations above, derived for bulk plane waves propagating in an unbounded transverse isotropic medium, predict the presence of four partial waves. These partial waves are the equivalent of the two shear and the two longitudinal partial waves described in the case of an isotropic plate described in Section 7.2. Consequently, the displacements inside the plate may be written as a superposition of partial waves
where the subscript i = p,m stands for the partial wave propagating with wave number component and respectively. By coupling these displacements along with the stresses (σ 11 = C 11(∂u 1/∂x 1) + C 13(∂u 3/∂x 3) and σ 13 = C 13(∂u 1/∂x 3 + ∂u 3/∂x 1) to the ones of the surrounding fluid, the global matrix gives
where X = e ikp.h/2, Y = e ikm.h/2, G p,m = C 11 k p,m + C 13 R p,m .k, H p,m = R p,m k p,m + k. By combining columns and rows, the determinant of the global matrix can be calculated as follows
The determinant on the left corresponds to the anti‐symmetric modes while the one on the right corresponds to the symmetric modes. This determines the dispersion relation for the different modes of a wave propagating along a transverse isotropic elastic plate in a direction parallel to the fibers. In this case the velocity dispersion curve will depend on following elastic constants: , , , and . To introduce viscosity, the elastic constant should be considered as complex number.
To solve the problem of guided wave propagation in the direction perpendicular to the fibers it is important to note that this is the same problem of wave propagation along the parallel direction but in a different reference frame. Thus, it suffices to change the subscript 3 to 2 and replace C 55 by C 66 in Eqs. (7.39) to (7.42) to re‐obtain Eq. (7.46). However, since the plate is transverse isotropic: C 11 = C 22 and C 12 = C 11 – 2C 66. Under these conditions H p,m, G p,m, and k p,m are reduced to the following expressions
Consequently Eq. (7.46) may be reduced to Eqs. (7.28) and (7.29), which corresponds to the Leaky Lamb wave equation for an isotropic plate of shear wave speed of (C 66/ρ)1/2 and longitudinal wave speed of (C 11/ρ)½. Again, to introduce viscosity C 66 may be considered to obey a Voigt model, thus, C 66 = c 66 + iη 66.
Throughout this chapter the main features of transverse wave propagation in plate structures with application to ultrasound elastography have been reviewed. Wave propagation in such a configuration may be described as a superposition of different modes of propagation (e.g. symmetric/anti‐symmetric modes) which depend on the geometry, isotropy, mechanical properties, and boundary conditions of the wave guide. Moreover, the generation of each mode will depend on the frequency and type of source used in the experiments. In this scenario, it is mandatory to take the dispersive nature of each mode into account in order to retrieve the shear wave speed of the plate, otherwise bias in the shear wave speed estimation will be introduced. For a given application, once a plate model is assumed (e.g. plate in water, plate in vacuum, etc.) the shear wave speed of the plate may be retrieved by identifying the corresponding mode and fitting the theoretical dispersion curve to the experimental data. At the moment, the only mode that was consistently detected using ultrasound elastography is the zero ‐order anti‐symmetric mode. However, new applications will shortly lead to the detection of other types of modes as well as to the development of the theory for different types of geometries, sources, wave guides, etc.
The author would like to thank Dr. Nicolás Benech, Dr. Carlos Negreira, and Dr. Xiaoping Jia for the interesting discussions on guided wave generation and propagation. Javier Brum is supported by PEDECIBA‐Física, Uruguay and Agencia Nacional de Investigación e Innovación (ANII), Uruguay.
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