Contents

Cover

Title Page

Copyright

Dedication

Preface

Acknowledgements

List of Symbols

List of Acronyms

Chapter 1: What are Chemical Sensors?

1.1 Chemical Sensors: Definition and Components

1.2 Recognition Methods

1.3 Transduction Methods

1.4 Sensor Configuration and Fabrication

1.5 Sensor Calibration

1.6 Sensor Figures of Merit

1.7 Sensor Arrays

1.8 Sensors in Flow Analysis Systems

1.9 Applications of Chemical Sensors

1.10 Literature on Chemical Sensors and Biosensors

1.11 Organization of the Text

References

Chapter 2: Protein Structure and Properties

2.1 Amino Acids

2.2 Chemical Structure of Proteins

2.3 Conformation of Protein Macromolecules

2.4 Noncovalent Chemical Bonds in Protein Molecules

2.5 Recognition Processes Involving Proteins

2.6 Outlook

References

Chapter 3: Enzymes and Enzymatic Sensors

3.1 General

3.2 Enzyme Nomenclature and Classification

3.3 Enzyme Components and Cofactors

3.4 Some Enzymes with Relevance to Biosensors

3.5 Transduction Methods in Enzymatic Biosensors

3.6 Kinetics of Enzyme Reactions

3.7 Enzyme Inhibition

3.8 Concluding Remarks

References

Chapter 4: Mathematical Modeling of Enzymatic Sensors

4.1 Introduction

4.2 The Enzymatic Sensor under External Diffusion Conditions

4.3 The Enzymatic Sensor under Internal Diffusion Control

4.4 The General Case

4.5 Outlook

References

Chapter 5: Materials and Methods in Chemical-Sensor Manufacturing

5.1 Introduction

5.2 Noncovalent Immobilization at Solid Surfaces

5.3 Covalent Conjugation

5.4 Supports and Support Modification

5.5 Affinity Reactions

5.6 Thin Molecular Layers

5.7 Sol-Gel Chemistry Methods

5.8 Hydrogels

5.9 Conducting Polymers

5.10 Encapsulation

5.11 Entrapment in Mesoporous Materials

5.12 Polymer Membranes

5.13 Microfabrication Methods in Chemical-Sensor Technology

5.14 Concluding Remarks

References

Chapter 6: Affinity-Based Recognition

6.1 General Principles

6.2 Immunosensors

6.3 Immobilization Methods in Immunosensors

6.4 Immunoassay Formats

6.5 Protein and Peptide Microarrays

6.6 Biological Receptors

6.7 Artificial Receptors

6.8 Outlook

References

Chapter 7: Nucleic Acids in Chemical Sensors

7.1 Nucleic Acid Structure and Properties

7.2 Nucleic Acid Analogs

7.3 Nucleic Acids as Receptors in Recognition Processes

7.4 Immobilization of Nucleic Acids

7.5 Transduction Methods in Nucleic Acids Sensors

7.6 DNA Microarrays

7.7 Outlook

References

Chapter 8: Nanomaterial Applications in Chemical Sensors

8.1 Generals

8.2 Metallic Nanomaterials

8.3 Carbon Nanomaterials

8.4 Polymer and Inorganic Nanofibers

8.5 Magnetic Micro- and Nanoparticles

8.6 Semiconductor Nanomaterials

8.7 Silica Nanoparticles

8.8 Dendrimers

8.9 Summary

References

Chapter 9: Thermochemical Sensors

9.1 Temperature Transducers

9.2 Enzymatic Thermal Sensors

9.3 Thermocatalytic Sensors for Combustible Gases

References

Chapter 10: Potentiometric Sensors

10.1 Introduction

10.2 The Galvanic Cell at Equilibrium

10.3 Ion Distribution at the Interface of Two Electrolyte Solutions

10.4 Potentiometric Ion Sensors – General

10.5 Sparingly Soluble Solid Salts as Membrane Materials

10.6 Glass Membrane Ion Sensors

10.7 Ion Sensors Based on Molecular Receptors. General Aspects

10.8 Liquid Ion Exchangers as Ion Receptors

10.9 Neutral Ion Receptors (Ionophores)

10.10 Molecularly Imprinted Polymers as Ion-Sensing Materials

10.11 Conducting Polymers as Ion-Sensing Materials

10.12 Solid Contact Potentiometric Ion Sensors

10.13 Miniaturization of Potentiometric Ion Sensors

10.14 Analysis with Potentiometric Ion Sensors

10.15 Recent Advances in Potentiometric Ion Sensors

10.16 Potentiometric Gas Sensors

10.17 Solid Electrolyte Potentiometric Gas Sensors

10.18 Potentiometric Biocatalytic Sensors

10.19 Potentiometric Affinity Sensors

10.20 Summary

References

Chapter 11: Chemical Sensors Based on Semiconductor Electronic Devices

11.1 Electronic Semiconductor Devices

11.2 FED Ion Sensors and Their Applications

11.3 FED Gas Sensors

11.4 Schottky-Diode-Based Gas Sensors

11.5 Carbon-Nanotube-Based Field-Effect Transistors

11.6 Concluding Remarks

References

Chapter 12: Resistive Gas Sensors (Chemiresistors)

12.1 Semiconductor Metal Oxide Gas Sensors

12.2 Organic-Material-Based Chemiresistors

12.3 Nanomaterial Applications in Resistive Gas Sensors

12.4 Resistive Gas Sensor Arrays

12.5 Summary

References

Chapter 13: Dynamic Electrochemistry Transduction Methods

13.1 Introduction

13.2 Electrochemical Cells in Amperometric Analysis

13.3 The Electrolytic Current and its Analytical Significance

13.4 Membrane-Covered Electrodes

13.5 Non-Faradaic Processes

13.6 Kinetics of Electrochemical Reactions

13.7 Electrochemical Methods

13.8 Electrode Materials

13.9 Catalysis in Electrochemical Reactions

13.10 Amperometric Gas Sensors

References

Chapter 14: Amperometric Enzyme Sensors

14.1 First-Generation Amperometric Enzyme Sensors

14.2 Second-Generation Amperometric Enzyme Sensors

14.3 The Mediator as Analyte

14.4 Conducting Polymers in Amperometric Enzyme Sensors

14.5 Direct Electron Transfer: 3rd-Generation Amperometric Enzyme Sensors

14.6 NAD/NADH++ as Mediator in Biosensors

14.7 Summary

References

Chapter 15: Mathematical Modeling of Mediated Amperometric Enzyme Sensors

15.1 External Diffusion Conditions

15.2 Internal Diffusion Conditions

References

Chapter 16: Electrochemical Affinity and Nucleic Acid Sensors

16.1 Amperometric Affinity Sensors

16.2 Electrochemical Nucleic Acid-Based Sensors

References

Chapter 17: Electrical-Impedance-Based Sensors

17.1 Electrical Impedance: Terms and Definitions

17.2 Electrochemical Impedance Spectrometry

17.3 Electrochemical Impedance Affinity Sensors

17.4 Biocatalytic Impedimetric Sensors

17.5 Outlook

17.6 Nucleic Acid Impedimetric Sensors

17.7 Conductometric Sensors

17.8 Impedimetric Sensors for Gases and Vapors

References

Chapter 18: Optical Sensors – Fundamentals

18.1 Electromagnetic Radiation

18.2 Optical Waveguides in Chemical Sensors

18.3 Spectrochemical Transduction Methods

18.4 Transduction Schemes in Spectrochemical Sensors

18.5 Fiber Optic Sensor Arrays

18.6 Label-Free Transduction in Optical Sensors

18.7 Transduction by Photonic Devices

References

Chapter 19: Optical Sensors – Applications

19.1 Optical Sensors Based on Acid–Base Indicators

19.2 Optical Ion Sensors

19.3 Optical Oxygen Sensors

19.4 Optical Enzymatic Sensors

19.5 Optical Affinity Sensors

19.6 Optical DNA Sensors and Arrays

References

Chapter 20: Nanomaterial Applications in Optical Transduction

20.1 Semiconductor Nanocrystals (Quantum Dots)

20.2 Carbon Nanotubes as Optical Labels

20.3 Metal Nanoparticle in Optical Sensing

20.4 Porous Silicon

20.5 Luminescent Lanthanide Compound Nanomaterials

20.6 Summary

References

Chapter 21: Acoustic-Wave Sensors

21.1 The Piezoelectric Effect

21.2 The Thickness–Shear Mode Piezoelectric Resonator

21.3 QCM Gas and Vapor Sensors

21.4 QCM Affinity Sensors

21.5 QCM Nucleic Acid Sensors

21.6 Surface-Launched Acoustic-Wave Sensors

21.7 Summary

References

Chapter 22: Microcantilever Sensors

22.1 Principles of Microcantilever Transduction

22.2 Measurement of Cantilever Deflection

22.3 Functionalization of Microcantilevers

22.4 Microcantilever Gas and Vapor Sensors

22.5 Microcantilever Affinity Sensors

22.6 Enzyme Assay by Microcantilever Sensors

22.7 Microcantilever Nucleic Acid Sensors

22.8 Outlook

References

Chapter 23: Chemical Sensors Based on Microorganisms, Living Cells and Tissues

23.1 Living Material Biosensors: General Principles

23.2 Sensing Strategies in Living-Material-Based Sensors

23.3 Immobilization of Living Cells and Microorganisms

23.4 Electrochemical Microbial Biosensors

23.5 Optical Whole-Cell Sensors

23.6 Improving the Selectivity of Microorganism Biosensors

23.7 Conclusions

References

Index

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