The Gene Ontology (GO) is a very useful restricted vocabulary of annotation terms for genes and gene products that describe the biological process, molecular function, or cellular component of an annotated entity. As such, the terms are extremely useful as data in such things as gene-set enrichment analysis and other functional -omics approaches. In this recipe, we'll look at how we can prepare a list of gene IDs in a genomic region and get the GO IDs and descriptions for them all.