Table of Contents

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Woodhead Publishing Series in Biomaterials

Part I: Fundamentals of joining and assembly in medical materials and devices

Chapter 1: Introduction to medical materials and devices

Abstract:

1.1 Introduction

1.2 The anatomy of interaction

1.3 Materials for drug delivery

1.4 The metrology of biocompatibility

1.5 Conclusion

1.6 Future trends

Chapter 2: Introduction to joining methods in medical applications

Abstract:

2.1 Introduction

2.2 Welding processes

2.3 Adhesive bonding

2.4 Examples of applications

Chapter 3: Microwelding methods in medical components and devices

Abstract:

3.1 Introduction

3.2 Materials challenges

3.3 Medical components and devices

3.4 Joint design and process selection

3.5 Testing and verification

3.6 Conclusion and future trends

Chapter 4: The effects of sterilization on medical materials and welded devices

Abstract:

4.1 Introduction to sterilization

4.2 Sterilization methods

4.3 The effects of sterilizing on different materials

4.4 The effects of sterilizing on welded joints

4.5 Selecting a suitable sterilization method

4.6 Conclusions

Part II: Joining and assembly of medical metals

Chapter 5: Micro-welding of shape-memory alloys

Abstract:

5.1 Introduction

5.2 Fundamentals of Nitinol shape-memory alloys

5.3 Micro-welding of NiTi

5.4 Future trends

5.5 Conclusion

Chapter 6: Joining of platinum (Pt) alloy wires to stainless steel wires for electronic medical devices

Abstract:

6.1 Introduction

6.2 Material properties

6.3 Material challenges in joining

6.4 The crossed-wire joint

6.5 Joining processes

6.6 Future trends

6.7 Conclusions

Chapter 7: Evaluating the corrosion performance of metal medical device welds

Abstract:

7.1 Introduction

7.2 Measurements of corrosion

7.3 Direct measurements of corrosion current

7.4 Considerations when gathering corrosion data

7.5 Test sample preparation

7.6 Instrumentation and equipment

7.7 Interpretation of data

7.8 Mitigations for weld corrosion

7.9 Future trends

7.10 Sources of further information

Chapter 8: Laser hermetic welding of implantable medical devices

Abstract:

8.1 Introduction

8.2 Hermetic-sealing techniques

8.3 Laser conduction welding

8.4 Focused laser beams

8.5 Laser welding parameters

8.6 Requirements for laser hermetic welds

8.7 Conclusion and future trends

Chapter 9: Validating hermeticity in welded metallic implantable medical devices

Abstract:

9.1 Introduction

9.2 The physics of leak rates

9.3 Measurement of leak rates – testing and verification

9.4 Determining leak rate based on helium content

Part III: Joining and assembly of medical plastics

Chapter 10: Overview of welding methods for medical plastics

Abstract:

10.1 Introduction

10.2 Fundamental processes of plastics welding

10.3 Medical plastics and weldability

10.4 Part and Joint Design

10.5 Processes with external heating

10.6 Processes with internal heating

10.7 Processes with implant welding

10.8 Potential impacts from other manufacturing processes

10.9 Special applications for welding of medical plastics

Chapter 11: Ultrasonic welding of medical plastics

Abstract:

11.1 Introduction

11.2 Ultrasonic-welding processes fundamentals

11.3 Ultrasonic-welding process parameters and control

11.4 Weldability

11.5 Horn design

11.6 Part and joint design

11.7 Process optimization

11.8 Other specific applications

11.9 Troubleshooting

11.10 Advantages and limitations

Chapter 12: Radio frequency (RF)/dielectric welding of medical plastics

Abstract:

12.1 Introduction

12.2 Dielectric heating fundamentals

12.3 Dielectric welding/sealing process description and process parameters

12.4 Key factors affecting the sealing process and seal quality

12.5 Weldability

12.6 Testing approaches for seals and the dielectric sealing process

12.7 RF welding process advantages, limitations and future trends

Chapter 13: Transmission laser welding strategies for medical plastics

Abstract:

13.1 Introduction

13.2 Advantages and limitations of laser welding

13.3 Process description

13.4 Main welding parameters and effects

13.5 Forms of equipment

13.6 Weldable materials

13.7 Joint designs

13.8 Monitoring and quality control

13.9 Applications

Chapter 14: Bonding strategies and adhesives for joining medical device components

Abstract:

14.1 Introduction

14.2 Designing a joint with adhesive

14.3 Mechanisms of adhesion

14.4 Adhesion promotion

14.5 Types of adhesives used in medical devices

14.6 Conclusion

Part IV: Joining and assembly of biomaterial and tissue implants

Chapter 15: Advanced metal–ceramic joining techniques for orthopaedic applications

Abstract:

15.1 Introduction

15.2 The challenges of joining metals to ceramics

15.3 Mechanical joining techniques

15.4 Direct and indirect bonded joining techniques

15.5 Active brazing joining techniques

15.6 Future trends

Chapter 16: Tissue adhesives and sealants for surgical applications

Abstract:

16.1 Introduction

16.2 Principles of tissue adhesives and sealants

16.3 Definitions and general considerations

16.4 Mechanisms of bonding

16.5 Application methods

16.6 Synthetic bioresorbable sealants

16.7 Commercial resorbable synthetic sealants and adhesives

16.8 Commercial resorbable bio-derived sealants and adhesives

16.9 Commercial biostable bio-derived sealants and adhesives

16.10 Commercial biostable synthetic sealants and adhesives

16.11 Conclusion

Chapter 17: Antibacterial adhesives for bone and tooth repair

Abstract:

17.1 Introduction to tooth repair

17.2 Introduction to bone repair

17.3 Future trends

17.4 Acknowledgment

Chapter 18: Testing bond strength: the case of dental biomaterials

Abstract:

18.1 Introduction

18.2 Rationale for bond strength testing

18.3 Classification of dental adhesive testing techniques

18.4 Behavioural adhesive tests

18.5 Structural adhesive tests

18.6 Future trends

18.7 Conclusion

Index

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