This chapter shows how to enter data and prepare SAS programs to perform a two-way mixed-design ANOVA using the REPEATED statement with the GLM procedure. Guidelines for the hierarchical interpretation of the analysis are provided. This chapter shows how to interpret a significant interaction between the repeated-measures factor and the between-subjects factor as well as how to interpret main effects in the absence of an interaction. It also provides an alternative method of performing the analysis that allows for use of a variety of SAS/STAT post-hoc multiple-comparisons tests.